A New Disease Severity Score for Measuring Treatment Response to Adrenalectomy in Patients With Primary Aldosteronism
Authors' conclusion
Although complete cure rates are low after adrenalectomy in primary aldosteronism, especially based on the new definition of normal blood pressure, a clinical improvement is seen in the vast majority of patients postoperatively. The newly introduced PADSS can be used to assess the clinical benefit achieved with adrenalectomy.
Study context
- Population
- Patients who underwent adrenalectomy for PA, 2000–2023; adrenalectomy guided by AVS in 86.1%
- Participants
- 201 patients
- Exposure
- Preoperative vs 6-month postoperative Primary Aldosteronism Disease Severity Score (PADSS) after adrenalectomy
- Outcome
- Cure rate per current definition of normal blood pressure, and clinical improvement measured by new PA Disease Severity Score (PADSS: blood pressure, defined daily dose of antihypertensives, potassium supplementation)
- Follow-up
- 6 months postoperative
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
6 months
- Cure rate per new definition of normal blood pressure
- 7.5% (n = 15)
- Median PADSS preoperatively
- 16.3 (13.6-19.9)
- Median PADSS postoperatively
- 10 (4.5-13.3)
- Improvement of PADSS at 6 months
- 90% (n = 180)
- Median rate of improvement in PADSS
- 33.3% (13.8% to 56.6%)
Observational data: associations, not effects.
Original publication
A New Disease Severity Score for Measuring Treatment Response to Adrenalectomy in Patients With Primary Aldosteronism. Endocr Pract. Published 11 September 2024. doi:10.
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