Suppressed Renin Status Is a Risk Factor for Cardiocerebrovascular Events in Bilateral Primary Aldosteronism Treated With Mineralocorticoid Receptor Antagonists
Authors' conclusion
Patients with BPA who receive pharmacologic treatment have a high incidence of CCVD. PRA may be an indicator that mineralocorticoids are being adequately antagonized.
Study context
- Population
- Patients with bilateral PA treated with mineralocorticoid receptor antagonists
- Participants
- 240 patients
- Exposure
- Suppressed vs unsuppressed posttreatment plasma renin activity
- Outcome
- Incidence of cardiocerebrovascular disease (CCVD)
Main finding
As reported in the abstract
CCVD · median follow-up 5.0 (range, 2.96-7.66) years
Each group vs PRA ≥1 ng/mL/hEstimate (95% CI)P value
PRA <1 ng/mL/h
HR 4.50(1.47–13.83)
P < 0.05PRA <1 ng/mL/h
aHR 3.98(1.22–13.02)
P < 0.05- Overall CCVD incidence
- 7.1% (17/240)
Observational data: associations, not effects.
Further findings
- Patients with plasma renin activity (PRA) ≥1 ng/mL/h after treatment
- 57.1%
Original publication
Suppressed Renin Status Is a Risk Factor for Cardiocerebrovascular Events in Bilateral Primary Aldosteronism Treated With Mineralocorticoid Receptor Antagonists. Endocr Pract. Published 10 September 2024. doi:10.
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