Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism
An erratum to this article was published (J Clin Endocrinol Metab, 15 Feb 2023 ↗)
Authors' conclusion
The reversal of arterial stiffness was found in PA patients receiving adrenalectomy and in medically treated PA patients with unsuppressed PRA.
Study context
- Population
- Patients with primary aldosteronism (PA) treated by adrenalectomy or mineralocorticoid receptor antagonist (MRAs)
- Participants
- 445 patients190 received MRAs
- Exposure
- Adrenalectomy vs MRA with suppressed plasma renin activity (PRA) vs MRA with unsuppressed PRA
- Group 1n = 255
- Outcome
- Change in PWV (ΔPWV)
- Follow-up
- 12 months after treatment
Methodological detailsrestricted cubic spline analysis
- Restricted cubic spline analysis
Main finding
As reported in the abstract
Improvement in PWV after treatment · 12 months
- Significant PWV improvement in group 1 and group 3 (both P < .001)
- No significant PWV improvement in group 2 (P = .151)
- Group 2 vs Group 1: P = 0.007
- Group 2 vs Group 3: P = 0.031
- ANOVA and post hoc analysis
Observational data: associations, not effects.
Further findings
Best cutoff of posttreatment PRA (restricted cubic spline (RCS) model)
- Best cutoff posttreatment PRA
- 1.5 ng/mL/h
Independent factors correlated with ΔPWV in MRA-treated patients
- Log-transformed posttreatment PRA, age and baseline PWV were independent factors
- Multivariable regression
Original publication
Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism. J Clin Endocrinol Metab. Published 5 November 2022. doi:10.
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