Prognostic value of contralateral suppression on kidney function after surgery in patients with primary aldosteronism
Authors' conclusion
This retrospective study found that CLS was a strong and independent predictor of a marked reduction of eGFR and an increased risk of hyperkalemia after adrenalectomy in patients with PA.
Study context
- Population
- Patients with primary aldosteronism (PA) referred for adrenal venous sampling (AVS) between May 2011 and August 2021 and subsequently offered surgical or medical treatment85 adrenalectomy
- Participants
- 138 patients
- Exposure
- Contralateral suppression (CLS) vs no CLS in patients with PA undergoing adrenalectomy
- CLSn = 59
- No CLSn = 26reference
- Outcome
- Change in kidney function (estimated glomerular filtration rate (eGFR)) after adrenalectomy
Main finding
As reported in the abstract
Change in eGFR after adrenalectomy
| Group | Value | Direction |
|---|---|---|
| CLS | mean 17.5 (SD 17.6) | reduction |
| No CLS | mean 1.8 (SD 12.8) | increase |
Value
CLSmean 17.5 (SD 17.6)
No CLSmean 1.8 (SD 12.8)
Direction
CLSreduction
No CLSincrease
- CLS vs No CLS: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Surgically treated | Medically treated | P value |
|---|---|---|---|
| Reduction in eGFR, surgical vs medical treatment | 11.5 (SD 18.5) | 5.9 (SD 11.5) | P = 0.04 |
Safety
Post-surgery hyperkalemia
P = 0.04
Original publication
Prognostic value of contralateral suppression on kidney function after surgery in patients with primary aldosteronism. Clin Endocrinol (Oxf). Published 31 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →