Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas
Authors' conclusion
This study is the first to report that ACS is accompanied by impaired cognitive function. Consequently, cognitive function assessment should be incorporated into the clinical evaluation of patients with ACS.
Study context
- Population
- Patients with AI undergoing a battery of validated neuropsychological testspatients with AI
- Participants
- 63 patients
- Exposure
- Autonomous cortisol secretion (ACS) vs NFA
- ACSn = 27
- NFAn = 36reference
- Outcome
- Neurocognitive function
Main finding
As reported in the abstract
- ACS vs NFA: P < 0.05
- ACS vs NFA: P < 0.05
- ACS vs NFA: all P < 0.05
Observational data: associations, not effects.
Further findings
Correlation of serum cortisol after 1-mg DST with working memory and visuospatial/constructional domains
- R, working memory
- −0.307
- R, visuospatial/constructional
- −0.306
- P
- all P < 0.05
- Gradual deterioration with increasing cortisol after 1-mg DST
- all P values for trend < 0.05
Multivariate linear regression: cortisol after 1-mg DST as risk factor for impairment
- B, working memory
- −0.006
- B, visuospatial/constructional
- −0.043
- P
- all P < 0.05
Original publication
Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas. J Clin Endocrinol Metab. Published 20 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →