Leukocyte Telomere Length in Children With Congenital Adrenal Hyperplasia
Authors' conclusion
LTL is shorter in patients with classic than nonclassic CAH, and in those who are overtreated with hydrocortisone or treated with long-acting glucocorticoids. These findings may be attributed to chronic exposure to supraphysiologic glucocorticoid concentrations and indicate that LTL may be used as a biomarker for monitoring glucocorticoid treatment.
Study context
- Population
- Children with genetically confirmed CAH; median age 12.0 years (IQR 6.3–15.1), 41% girls
- Exposure
- Leukocyte telomere length (LTL) by CAH type, treatment status and glucocorticoid type
- Classic CAHn = 63
- Prednisolonen = 8
- Hydrocortisonen = 67reference
- Outcome
- Leukocyte telomere length (LTL) by quantitative real-time PCR
- Follow-up
- 2 visits (mean 4.1 ± 0.7 months apart)
Methodological detailsmulticentre, 4 academic pediatric endocrinology outpatient clinics, linear mixed models adjusted for age, sex and BMI-z
- Multicentre
- 4 academic pediatric endocrinology outpatient clinics
- Linear mixed models adjusted for age, sex and BMI-z
Main finding
As reported in the abstract
Classic CAH vs Nonclassic CAH · shorter with classic CAH
−0.29
P = 0.012
Overtreated vs Optimally treated · shorter when overtreated
−0.07
P = 0.002
Prednisolone vs Hydrocortisone · shorter with prednisolone
−0.34
P < 0.001
- LTL not associated with undertreatment or daily hydrocortisone-equivalent dose
- P > 0.05
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →