Characterisation of the urinary steroid profile of patients with nonfunctioning adrenal incidentalomas: A matched controlled cross‐sectional study
Authors' conclusion
NFAIs seem to secrete a subtle, yet clinically relevant, excess of glucocorticoids. Future studies are needed to confirm our findings; and to identify metabolic alterations associated with an increased cardiometabolic risk.
Study context
- Population
- Patients with nonfunctioning adrenal incidentalomas, patients with ACS and patients without adrenal tumours
- Participants
- 73 patients
- Exposure
- NFAI vs healthy-adrenal controls and ACS
- NFAIn = 24
- Healthy-adrenaln = 24reference
- ACSn = 25
- Outcome
- Urinary steroid profile (24-h urine, gas chromatography–mass spectrometry)
Methodological detailsmatched controlled, matched on sex, age (±5 years) and BMI (±5 kg/m²)
- Matched controlled
- Matched on sex, age (±5 years) and BMI (±5 kg/m²)
Main finding
As reported in the abstract
Urinary steroid excretion, NFAI vs healthy-adrenal
- NFAI vs Healthy-adrenal: P = 0.046
- NFAI vs Healthy-adrenal: P = 0.038
Observational data: associations, not effects.
Further findings
| Outcome | NFAI | Healthy-adrenal | ACS | P value |
|---|---|---|---|---|
| UFC above reference rangeNFAI vs Healthy-adrenal | 20.8% | 0% | — not stated in the abstract | P = 0.018 |
| Androgen metabolites, ACS vs NFAILower with ACS | 231 ± 190 µg/24 h | — not stated in the abstract | 218.4 ± 204.24 µg/24 h | P = 0.041 |
| Glucocorticoid metabolites, ACS vs NFAINonsignificantly higher with ACS | 1550.8 ± 810.03 µg/24 h | — not stated in the abstract | 2129.6 ± 1195.96 µg/24 h | P = 0.180 |
— not stated in the abstract
Cardiometabolic comorbidities
- ACS had a higher prevalence of hypertension, dyslipidemia and diabetes than NFAI or controls
Original publication
Characterisation of the urinary steroid profile of patients with nonfunctioning adrenal incidentalomas: A matched controlled cross‐sectional study. Clin Endocrinol (Oxf). Published 22 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →