Evaluation of Body Composition in Patients With and Without Adrenal Tumors and Without Overt Hypersecretory Syndromes
Authors' conclusion
The urinary steroid profile observed in adrenal tumors, comprising a low excretion of androgen metabolites and high excretion of glucocorticoid metabolites, is associated with a lower lean mass and bone mass and higher level of visceral mass in patients with adrenal tumors.
Study context
- Population
- Patients with autonomous cortisol secretion (ACS), nonfunctioning adrenal incidentalomas (NFAIs) and controls without adrenal tumors, without overt hypersecretory syndromes
- Participants
- 25 / 24 / 24
- Exposure
- ACS vs NFAI vs controls without adrenal tumors
- ACSn = 25
- NFAIsn = 24
- Controln = 24reference
- Outcome
- Correlations of body composition with cortisol and urinary steroid profile
Methodological detailsmatched by age (±5 years), sex and BMI (±5 kg/m²)
- Matched by age (±5 years), sex and BMI (±5 kg/m²)
Main finding
As reported in the abstract
- Serum cortisol post-DST vs subcutaneous fat area (computed tomography (CT)), weak positive correlation
- r = 0.3, P =.048
- Lean mass vs total androgen excretion (bioelectrical impedance)
- r = 0.56, P <.001
- Bone mass vs total androgen excretion (bioelectrical impedance)
- r = 0.58, P <.001
- Visceral mass vs glucocorticoid metabolite excretion (bioelectrical impedance)
- r = 0.28, P =.031
- Visceral mass vs total glucocorticoid excretion (bioelectrical impedance)
- r = 0.42, P =.001
- Lean mass vs androgen metabolites (CT)
- r = 0.30, P =.036
- Visceral fat area vs glucocorticoid metabolite excretion (CT)
- r = 0.34, P =.014
- Total fat area vs glucocorticoid metabolite excretion (CT)
- r = 0.29, P =.042
- Visceral/total fat area ratio vs glucocorticoid metabolite excretion (CT)
- r = 0.31, P =.170
Observational data: associations, not effects.
Original publication
Evaluation of Body Composition in Patients With and Without Adrenal Tumors and Without Overt Hypersecretory Syndromes. Endocr Pract. Published 28 November 2022. doi:10.
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