Salivary 17-Hydroxyprogesterone Levels in Children with Congenital Adrenal Hyperplasia: A Retrospective Longitudinal Study Considering Auxological Parameters
Authors' conclusion
The measurement of s17-OHP is an important sub-aspect in the overall assessment of treatment response in CAH. It can provide an indication of over-/undertreatment and allows the assessment of day profiles, especially in phases of changing (e.g., puberty) steroid requirements. We present here observational data from a larger cohort with longitudinal multiple measurements of s17-OHP. The values do not allow a significant differentiation between normal and abnormal growth or pubertal status. Thus, relying solely on s17-OHP is not advisable.
Study context
- Population
- Children with classical congenital adrenal hyperplasia (CAH) due to 21-hydroxylase dysfunction on glucocorticoid replacement546 saliva samples
- Participants
- 22 children
- Exposure
- Normal vs abnormal auxological development; prepubertal vs pubertal
- Outcome
- Salivary 17-OHP (s17-OHP), total cohort
- Follow-up
- Median observation 5.5 years per patient
Main finding
As reported in the abstract
Median s17-OHP, morning
67.8 pg/mL
Median s17-OHP, noon
42.5 pg/mL
Median s17-OHP, evening
25.0 pg/mL
s17-OHP values attributed to normal auxological development
72.5%
Observational data: associations, not effects.
Further findings
Samples collected in prepubertal children
- Samples from prepubertal children
- 57.1%
Safety
- No precocious pubertal development, abnormal vital signs or Addison crises occurred
Original publication
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