Ethnic and National Differences in Congenital Adrenal Hyperplasia Incidence: A Systematic Review and Meta-Analysis
Authors' conclusion
This study highlights the at-risk population for CAH and regions that need monitoring for CAH. The highest CAH incidence could be attributed to higher consanguinity, less genetic diversity, or other genetic causes since CAH is an inherited genetic disorder. Cultural practices in some places regarding consanguineous unions or geographic isolation may directly affect the incidence. Newborn screening for CAH may be unavailable in many developing countries, thereby affecting the actual CAH incidence. Therefore, healthcare workers should be trained to recognize CAH at an early stage to reduce its complications and mortality.
Study context
- Population
- Studies reporting incidence of classic congenital adrenal hyperplasia (CAH) (salt-wasting and simple-virilizing), 31 countries, 1969–201758 studies
- Comparison
- CAH incidence by country, region and ethnicity
- Outcome
- CAH incidence (classic type)
Methodological detailsPubMed, Scopus and LILACS searched until June 22, 2018, Only classic CAH considered; no distinction between enzyme deficiency types
- PubMed, Scopus and LILACS searched until June 22, 2018
- Only classic CAH considered; no distinction between enzyme deficiency types
Pooled result
As reported in the abstract
Overall CAH incidence
1:9,498
95% CI 1:9,089, 1:9,945
Original publication
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