Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features?
Authors' conclusion
NFAI and ACS presented a higher frequency of cardiometabolic morbidities in comparison with individuals with normal adrenal glands. Additionally, we demonstrated that both ACS and NFAI groups have similar cardiometabolic conditions.
Study context
- Population
- Patients with adrenal incidentaloma (nonfunctioning adrenal incidentalomas (NFAI) or autonomous cortisol secretion (ACS)) and controls with normal adrenal imaging
- Exposure
- NFAI vs ACS vs controls
- Outcome
- Cardiometabolic clinical parameters
Main finding
As reported in the abstract
Cardiometabolic morbidities, adrenal incidentaloma vs controls
- Adrenal incidentaloma vs Controls
- hypertension 74.1 vs. 57.8%; P = 0.02
- Adrenal incidentaloma vs Controls
- resistant hypertension 45.4 vs. 9.4%; P < 0.001
- Adrenal incidentaloma vs Controls
- dyslipidemia 80.1 vs. 63.9%; P = 0.01
- Adrenal incidentaloma vs Controls
- metabolic syndrome 84.2 vs. 61.7%; P = 0.001
Observational data: associations, not effects.
Further findings
Independent predictors (binary logistic regression)
- NFAI independent predictor of resistant hypertension
- P = 0.004
- ACS independent predictor of resistant hypertension
- P = 0.001
- Model for resistant hypertension
- P = 0.003
- ACS independent predictor of metabolic syndrome
- P = 0.04
Baseline characteristics
- No differences between groups in age, gender, ethnicity, menopause or BMI
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Adrenal incidentaloma: Do patients with apparently nonfunctioning mass or autonomous cortisol secretion have similar or different clinical and metabolic features? Clin Endocrinol (Oxf). Published 9 January 2023. doi:10.
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