Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency
Authors' conclusion
Home waking salivary cortisone sampling has accuracy for the diagnosis of adrenal insufficiency similar to that of a standard ACTH stimulation test. Patients found the at-home test to be more convenient than the hospital-based test.
Study context
- Population
- Patients at high risk of AI
- Participants
- 220 patients
- Comparison
- Home waking salivary cortisone vs ACTH stimulation test
- Outcome
- Diagnostic accuracy of waking salivary cortisone for AI
Methodological detailsprospective
- Prospective
Performance
As reported in the abstract
| Test or model | AUC | NPV | PPV |
|---|---|---|---|
| Waking salivary cortisone | 0.95 (95% CI, 0.92 to 0.97) | 96% (95% CI, 90 to 99) | 95% (95% CI, 87 to 99) |
Waking salivary cortisone
AUC0.95 (95% CI, 0.92 to 0.97)
NPV96% (95% CI, 90 to 99)
PPV95% (95% CI, 87 to 99)
- Prevalence of AI by ACTH stimulation test
- 44%
Further findings
Information similar to ACTH stimulation test
- Participants in whom waking salivary cortisone gave information similar to ACTH stimulation test
- 70%
Patient preference
- Preferred home salivary collection to clinic attendance
- 83%
Original publication
Home Waking Salivary Cortisone to Screen for Adrenal Insufficiency. NEJM Evid. Published 6 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →