Factors Predicting Long-term Estimated Glomerular Filtration Rate Decrease, a Reliable Indicator of Renal Function After Adrenalectomy in Primary Aldosteronism
Authors' conclusion
We provide evidence that old age, high systolic blood pressure, baseline hypokalemia, and low eGFR are associated with an increased risk of postoperative long-term eGFR decrease in patients with PA postoperatively. More attention should be given to the above factors for the timely prevention and management of renal impairment.
Study context
- Population
- Patients with PA after adrenalectomy
- Participants
- 1,159 patients8 studies
- Outcome
- Postoperative long-term eGFR decrease
Methodological detailsDatabases searched: PubMed, Web of Science, Embase, Cochrane Library
- Databases searched: PubMed, Web of Science, Embase, Cochrane Library
Pooled result
As reported in the abstract
Preoperative factors associated with long-term eGFR decrease after adrenalectomy
- Old age: OR 1.05, 95% CI 1.02-1.09, P = .001
- High systolic blood pressure: OR 1.05, 95% CI 1.01-1.09, P = .01
- Baseline hypokalemia: OR 0.08, 95% CI 0.02-0.30, P < .001
- Low estimated glomerular filtration rate (eGFR): OR 0.92, 95% CI 0.87-0.97, P = .001
Original publication
Factors Predicting Long-term Estimated Glomerular Filtration Rate Decrease, a Reliable Indicator of Renal Function After Adrenalectomy in Primary Aldosteronism. Endocr Pract. Published 20 December 2022. doi:10.
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