Prognostic models to predict complete resolution of hypertension after adrenalectomy in primary aldosteronism: A systematic review and meta‐analysis
Authors' conclusion
The PASO score, Utsumi nomogram and ARS model showed comparable discrimination performance to predict CRH in primary aldosteronism.
Study context
- Population
- Patients undergoing total adrenalectomy for PA; development and validation studies of prognostic models for complete resolution of hypertension (CRH)25 studies
- Comparison
- Prognostic models for predicting complete resolution of hypertension
- Outcome
- Predictive performance (AUC) of prognostic models for CRH after adrenalectomy
Methodological detailsSearched MEDLINE, Embase and Web of Science, 12 prognostic models identified; 3 with data from ≥3 external validation studies reported
- Searched MEDLINE, Embase and Web of Science
- 12 prognostic models identified; 3 with data from ≥3 external validation studies reported
Pooled result
As reported in the abstract
AUC for predicting CRH (models with ≥3 external validation studies)
| Group | Value | AUC | 95% PI |
|---|---|---|---|
| Primary aldosteronism surgical outcome (PASO) score | 0.81 (95% CI 0.74–0.86) | 0.81 | 0.04-1.00 |
| Utsumi nomogram | 0.79 (95% CI 0.72–0.85) | 0.79 | 0.03-1.00 |
| Aldosteronoma resolution score (ARS) model | 0.77 (95% CI 0.74–0.80) | 0.77 | 0.59-0.86 |
Value
Primary aldosteronism surgical outcome (PASO) score0.81 (95% CI 0.74–0.86)
Utsumi nomogram0.79 (95% CI 0.72–0.85)
Aldosteronoma resolution score (ARS) model0.77 (95% CI 0.74–0.80)
AUC
Primary aldosteronism surgical outcome (PASO) score0.81
Utsumi nomogram0.79
Aldosteronoma resolution score (ARS) model0.77
95% PI
Primary aldosteronism surgical outcome (PASO) score0.04-1.00
Utsumi nomogram0.03-1.00
Aldosteronoma resolution score (ARS) model0.59-0.86
Further pooled results
- ARS model AUC in studies with the same AVS-guided adrenalectomy rate as the models meta-analysed
- 0.80 · 95% CI 0.75–0.85
Original publication
Prognostic models to predict complete resolution of hypertension after adrenalectomy in primary aldosteronism: A systematic review and meta‐analysis. Clin Endocrinol (Oxf). Published 20 April 2023. doi:10.
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