Postoperative adrenocorticotropic hormone (ACTH)-stimulated aldosterone predicts biochemical outcome in primary aldosteronism
Authors' conclusion
Low postoperative ACTH stimulated PAC was predictive of biochemical remission. If confirmed, this approach could reduce follow-up visits to assess biochemical outcome.
Study context
- Population
- Patients with primary aldosteronism (PA) who underwent adrenalectomy and postoperative ACTH stimulation tests within the first week, German Conn's registry
- Participants
- 100 patients
- Exposure
- Postoperative ACTH-stimulated plasma aldosterone concentrations (PAC) for predicting primary aldosteronism surgical outcome (PASO) biochemical outcome
- Outcome
- Prediction of partial/absent biochemical remission by PASO criteria
- Follow-up
- 6-12 months after adrenalectomy
Main finding
As reported in the abstract
Prediction of partial/absent biochemical remission
| Group | Cut-off | Sensitivity | Specificity | AUC |
|---|---|---|---|---|
| Stimulated PAC | 58.5 pg/mL | 95% | 74% | 0.89 (CI 0.82-0.96) |
Stimulated PAC
Cut-off58.5 pg/mL
Sensitivity95%
Specificity74%
AUC0.89 (CI 0.82-0.96)
Observational data: associations, not effects.
Further findings
Biochemical remission (PASO) · 6-12 months after adrenalectomy
- Complete biochemical remission
- 81%
- Partial biochemical remission
- 13%
- Absent biochemical remission
- 6%
Complete clinical remission · 6-12 months after adrenalectomy
- Complete clinical remission
- 28%
Original publication
Postoperative ACTH-stimulated aldosterone predicts biochemical outcome in primary aldosteronism. Eur J Endocrinol. Published 4 December 2023. doi:10.
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