ACTH Stimulation and Oral Salt Loading Tests Detect Biochemical Outcome Early After Primary Aldosteronism Surgery
Authors' conclusion
AST and OST immediately after surgery can predict biochemical and clinical outcomes 1 year after surgery in patients with PA.
Study context
- Population
- Patients with primary aldosteronism (PA) who underwent adrenalectomy at one hospital, 2008–2020, with adrenocorticotropin stimulation test (AST) and OST within 15 days of surgery and biochemical outcome assessed 1 year after surgery
- Participants
- 268 patients
- Exposure
- B-com vs B-inc biochemical outcome 1 year after adrenalectomy; AST and OST performed within 15 days of surgery
- B-comn = 219reference
- B-incn = 49
- Outcome
- Prediction of biochemical outcome by early postoperative AST and OST
- Follow-up
- 1 year after surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AUC, plasma aldosterone concentration (PAC)/Cort at 30 minutes after ACTH loading
0.76
AUC, 24-hour urine aldosterone
0.77
Observational data: associations, not effects.
Original publication
ACTH Stimulation and Oral Salt Loading Tests Detect Biochemical Outcome Early After Primary Aldosteronism Surgery. J Clin Endocrinol Metab. Published 9 October 2024. doi:10.
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