Glucocorticoid Receptor Expression Pattern in Very Low Birth Weight Infants Changes Drastically within the First Week of Life
Authors' conclusion
The present results suggest that glucocorticoid sensitivity in VLBW infants increases after birth and this rapid change may play a role in surviving critical postnatal events.
Study context
- Population
- Very low birth weight (VLBW) and term infants; whole blood GRα and GRβ mRNA by RT-qPCR at birth and postnatal days 4–7
- Exposure
- VLBW infants vs term infants; day 0 vs days 4-7
- VLBWn = 43
- Outcome
- GRα/GRβ expression ratio change in VLBW infants (fold change)
- Follow-up
- Day 0 to days 4-7
Methodological detailslongitudinal
- Longitudinal
Main finding
As reported in the abstract
VLBW day 0
1.0
median · IQR 0.6–1.4 · fold change
VLBW days 4-7
1.7
median · IQR 0.6–1.4 · fold change
P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| GRα/GRβ expression ratio at birth, VLBW CS vs term planned CSSignificantly lower in VLBW (32 VLBW CS infants) | P < 0.05 |
Original publication
Glucocorticoid Receptor Expression Pattern in Very Low Birth Weight Infants Changes Drastically within the First Week of Life. Horm Res Paediatr. Published 28 September 2022. doi:10.
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