Whole blood transcriptomic signature of Cushing's syndrome
Authors' conclusion
Whole blood transcriptome reflects the circulating levels of glucocorticoids. FKBP5 expression could be a nonhormonal marker of Cushing's syndrome.
Study context
- Population
- Patients with overt CS, mild CS, eucortisolism and adrenal insufficiency
- Participants
- 57 samples
- Comparison
- Whole blood transcriptomic signature for identifying Cushing's syndrome
- Outcome
- Prediction of CS in the validation cohort
Methodological detailstraining and validation cohorts, whole blood RNA sequencing, ridge regression predictor
- Training and validation cohorts
- Whole blood RNA sequencing
- Ridge regression predictor
Performance
As reported in the abstract
| Test or model | Accuracy |
|---|---|
| 1500-gene predictor | .82 |
| FKBP5 | .76 |
Accuracy
1500-gene predictor.82
FKBP5.76
- 1500-gene predictor remained significant in a multivariate model including neutrophil proportion
- P = 0.002
Further findings
- Transcriptomic profile discriminated samples with overt CS
- Genes mostly associated with overt CS were enriched in immunity pathways, particularly neutrophil activation
Original publication
Whole blood transcriptomic signature of Cushing's syndrome. Eur J Endocrinol. Published 6 July 2024. doi:10.
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