The Prevalence of Obstructive Sleep Apnea in Patients With Primary Aldosteronism
Authors' conclusion
A substantial prevalence of OSA in individuals with PA was identified, demonstrating a complex interplay between these conditions in hypertensive patients. Notably, the prevalence of OSA was significantly associated with kidney hyperfiltration.
Study context
- Population
- Hypertensive patients with primary aldosteronism (PA), and hypertensive patients with obstructive sleep apnea (OSA); PubMed, Embase, CINAHL, Scopus and Web of Science searched up to September 2023
- Outcome
- Prevalence of OSA in PA and prevalence of PA in OSA, in hypertensive individuals
Methodological detailsproportional meta-analysis, random-effects model, meta-regression, subgroup analysis
- Proportional meta-analysis
- Random-effects model
- Meta-regression
- Subgroup analysis
Pooled result
As reported in the abstract
Prevalence of OSA in hypertensive PA patients
OSA prevalence in hypertensive PA
59.8%
Moderate-to-severe OSA in hypertensive PA
45.4%
PA prevalence in hypertensive OSA
11.2%
Further pooled results
Meta-regression of OSA prevalence
- Significant positive association with glomerular filtration rate (GFR)
- P < 0.001
- No significant effect of age, sex, BMI, antihypertensive medication, systolic or diastolic BP, or serum potassium
OSA prevalence with hyperfiltration (GFR ≥ 100 mL/min per 1.73 m²), subgroup analysis
- OSA prevalence with hyperfiltration
- 71%
- P value for interaction
- < .01
- May be associated with a higher prevalence of OSA
Original publication
The Prevalence of Obstructive Sleep Apnea in Patients With Primary Aldosteronism. J Clin Endocrinol Metab. Published 28 June 2024. doi:10.
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