Beyond symptomatology: A comparative analysis of unilateral and bilateral macronodular mild autonomous cortisol secretion
Authors' conclusion
DHEA-S levels may not be as suppressed in patients with bilateral macronodular MACS as compared to those with unilateral adenoma. T2DM and hypercholesterolaemia have a higher frequency in bilateral patients. However, ACTH, overnight 1 mg DST and SII may not provide additional information for differentiation of bilaterality and unilaterality.
Study context
- Population
- Patients with macronodular mild autonomous cortisol secretion (MACS); clinical, laboratory findings and magnetic resonance imaging (MRI) signal intensity index (SII) of adenomas and internodular areas
- Participants
- 81 patients
- Exposure
- Bilateral vs unilateral macronodular MACS
- Bilateraln = 35
- Unilateraln = 46reference
- Outcome
- Clinical, laboratory and MRI SII differences between groups
Methodological detailscomparative
- Comparative
Main finding
As reported in the abstract
- No significant difference in adrenocorticotropic hormone (ACTH) and overnight 1 mg dexamethasone suppression test (DST) between groups (p > .05)
- No difference in SII between adenomas within the same patient, or between unilateral and bilateral groups (p > .05)
- Unilateral vs Bilateral: P < 0.001
- Bilateral vs Unilateral: P < 0.05
Observational data: associations, not effects.
Further findings
Logistic regression for differentiation of unilateral vs bilateral macronodular MACS
- DHEAS, HbA1c and LDL-C concentrations were associated factors
Original publication
Beyond symptomatology: A comparative analysis of unilateral and bilateral macronodular mild autonomous cortisol secretion. Clin Endocrinol (Oxf). Published 27 June 2024. doi:10.
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