Plasma Metanephrines Yield Fewer False-Positive Results Than Urine Metanephrines in Patients With Obstructive Sleep Apnea
Authors' conclusion
In OSA patients, plasma metanephrines are less likely to yield false-positive results for the diagnosis of PPGL than 24-hour urinary metanephrines. In patients with suspected OSA, obesity, or a family history of hypertension, plasma metanephrines may be the preferred first-line test to avoid unnecessary anxiety or follow-up.
Study context
- Population
- Patients undergoing polysomnography for suspected obstructive sleep apnea (OSA); 68 (89.5%) had OSAcompleted testing
- Participants
- 76 patients
- Comparison
- Morning plasma free metanephrines vs 24-hour urinary metanephrines
- Outcome
- False-positive results for PPGL in OSA patients
Methodological detailsprospective recruitment
- Prospective recruitment
Performance
As reported in the abstract
False-positive metanephrines in OSA patients
P < 0.01
Further findings
False-positive urinary metanephrines by OSA severity · more common in severe OSA
P < 0.01
Elevated plasma and/or urinary metanephrines among OSA patients
- Elevated plasma and/or urinary metanephrines
- 19 (27.9%)
- PPGL diagnosed on follow-up (bladder paraganglioma)
- 1
Metanephrines after CPAP
- Both plasma and urinary metanephrines decreased after CPAP
Predictors of false-positive urinary metanephrines (multivariable)
- Severe OSA, obesity and family history of hypertension were positive predictors
Original publication
Plasma Metanephrines Yield Fewer False-Positive Results Than Urine Metanephrines in Patients With Obstructive Sleep Apnea. J Clin Endocrinol Metab. Published 18 September 2023. doi:10.
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