Survival probabilities in patients with ectopic Cushing's syndrome—a systematic review and a single-arm meta-analysis
Authors' conclusion
Survival in ECS varies considerably, mainly due to the underlying origin of the tumor, tumor stage, and severity of the hypercortisolism. Further studies analyzing the importance of factors affecting survival are needed.
Study context
- Population
- Patients with ectopic Cushing's syndrome (ECS); PubMed, Scopus and Web of Science searched up to October 18, 2023
- Participants
- 1,148 patients40 studies
- Comparison
- Pulmonary Neuroendocrine Neoplasm (NEN) vs Occult ECS vs Thymic NEN vs Pancreatic NEN
- Outcome
- Survival in patients with ECS
- Follow-up
- 1 and 5 years
Methodological detailsData extraction and risk of bias assessment by 3 independent investigators
- Data extraction and risk of bias assessment by 3 independent investigators
Pooled result
As reported in the abstract
Pooled mean survival probability, ECS of mixed etiologies
1-year survival probability
78%
5-year survival probability
47%
Further pooled results
5-year survival probability by ECS form
Factors influencing survival
- Studies reporting factors influencing survival
- 8
- Total resection of the primary tumor associated with better overall survival
- Unresectable tumors, metastatic disease at diagnosis, severe hypercortisolism, hypokalemia and new-onset DM associated with worse prognosis
Original publication
Survival probabilities in patients with ectopic Cushing's syndrome—a systematic review and a single-arm meta-analysis. Eur J Endocrinol. Published 2 June 2025. doi:10.
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