Clinical Significance of Skeletal Fat‐to‐Muscle Ratio in Idiopathic Hyperaldosteronism
Authors' conclusion
In this retrospective study, our findings suggest that FMR could serve as a valuable metric for early intervention and comanagement strategies in patients at risk of sarcopenic obesity. This approach could help block the progression from aldosterone-producing cell clusters to IHA, potentially inhibiting aldosterone overproduction in such patients.
Study context
- Population
- Patients with PA screened from those with secondary hypertension, subtyped via AVS; controls with essential hypertension
- Participants
- 199 vs 186
- Comparison
- Idiopathic hyperaldosteronism (IHA) vs essential hypertension (EH)
- IHAn = 199
- EHn = 186reference
- Outcome
- Correlation of FMR and insulin resistance (IR) with aldosterone production in IHA
Methodological detailsFat-to-muscle ratio (FMR) evaluated from adipose tissue and muscle distribution measured by a body composition analyzer
- FMR evaluated from adipose tissue and muscle distribution measured by a body composition analyzer
Main finding
As reported in the abstract
FMR, IR and IHA
- FMR positively associated with fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), aldosterone-to-renin ratio (ARR) and age
- Higher FMR linked to prevalence of IHA, with stepwise increase in risk from lowest to highest FMR quartile
- Logistic regression: both HOMA-IR and BMI contributed to elevated FMR
Observational data: associations, not effects.
Further findings
Glycaemic status and insulin sensitivity
- Prevalence of diabetes and prediabetes significantly higher in IHA vs EH
- Significantly higher hemoglobin A1c (HbA1c) and HOMA-IR, and much lower quantitative insulin sensitivity check index, in IHA vs EH
Original publication
Clinical Significance of Skeletal Fat‐to‐Muscle Ratio in Idiopathic Hyperaldosteronism. Clin Endocrinol (Oxf). Published 20 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →