Associations between thyroid function, thyroid diseases, and primary aldosteronism
Authors' conclusion
PA patients had lower thyroid function and higher prevalence of thyroid nodules compared to EH patients. Therefore, the screening of thyroid function and thyroid nodules may be indispensable for PA patients.
Study context
- Population
- Patients with primary aldosteronism (PA) or essential hypertension admitted to Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, August 2011 to June 2022; mean age 48.20 ± 8.83 years
- Participants
- 1,023 / 327 / 696 / 6,138
- Exposure
- PA vs essential hypertension
- PAn = 1,023
- Aldosterone-producing adenoma (APA)n = 327
- Idiopathic hyperaldosteronism (IHA)n = 696
- Essential hypertension (EH)n = 6,138reference
- Outcome
- Thyroid function and thyroid nodules in relation to PA and its subtypes
Methodological detailssingle-centre, multivariate logistic regression
- Single-centre
- Multivariate logistic regression
Main finding
As reported in the abstract
Thyroid nodules
Each group vs EHAdjusted odds ratio (95% CI)P value
PA
1.290(1.035–1.607)
P = 0.02IHA
1.316(1.005–1.724)
P = 0.04Observational data: associations, not effects.
Further findings
Thyroid function (FT4, FT3, TT4, TT3) and positive TPOAb
- PA and its subtypes had lower FT4, FT3, TT4, TT3 and prevalence of positive TPOAb than EH
Thyroid nodules by plasma aldosterone concentration (PAC)
- Higher prevalence of thyroid nodules with PAC ≥ 12 ng/dL vs <12 ng/dL
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Associations between thyroid function, thyroid diseases, and primary aldosteronism. Eur J Endocrinol. Published 21 August 2024. doi:10.
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