Sex-specific Associations of Aldosterone and Renin With Body Composition: A Population-based Cohort Study
Authors' conclusion
Independent of body weight, increased RAAS activity is associated with unfavorable differences in body composition; however, the strength and pattern of association varies by sex.
Study context
- Population
- Adults aged 40 to 69 years enrolled in CARTaGENE, 2009–2010, Québec (Canada); mean (SD) age 55 (8) years, BMI 27.3 (4.8) kg/m²
- Participants
- 3,687 adults
- Exposure
- Plasma aldosterone and renin concentrations vs body composition, by sex
- Outcome
- Body composition: waist circumference and WHR, lean body mass, fat mass and muscle mass (bioelectrical impedance), epicardial and pericardial adipose tissue volumes (cardiac MRI)
Main finding
As reported in the abstract
- Males: higher aldosterone and renin associated with increased waist circumference, WHR and fat mass, decreased lean body mass and muscle mass
- P < .05
- Males: aldosterone associated with increased ectopic cardiac adiposity
- P = .02
- Males: renin not associated with ectopic cardiac adiposity
- P = .43
- Females: higher renin associated with increased waist circumference, WHR and cardiac adiposity
- P < .05
- Females: aldosterone not associated with waist circumference, WHR or cardiac adiposity
- P ≥ .05
- Females: higher renin and aldosterone associated with increased fat mass
- P < .05
- Females: renin and aldosterone not associated with lean body mass or muscle mass
- P ≥ .05
Observational data: associations, not effects.
Original publication
Sex-specific Associations of Aldosterone and Renin With Body Composition: A Population-based Cohort Study. J Clin Endocrinol Metab. Published 16 August 2024. doi:10.
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