Prevalence of Psychiatric Comorbidities in Females With Classic Congenital Adrenal Hyperplasia
An erratum to this article was published (J Clin Endocrinol Metab, 16 Oct 2026 ↗)
Authors' conclusion
Females with classic CAH experience a higher burden of psychiatric illness, including anxiety and depression, than demographically similar men and women in the general population. The similar psychiatric burden between females with CAH and T1DM suggests that morbidity may be influenced by the challenges associated with managing a chronic condition. Investigating long-term mental health trajectories in this population will require longitudinal studies.
Study context
- Population
- Females with classic 46,XX congenital adrenal hyperplasia (CAH), 3 large integrated health systems
- Participants
- 115 / 1,150 / 1,150 / 66,002
- Exposure
- Females with classic CAH vs matched general population males and females and females with T1D
- CAHn = 115
- General population malesn = 1,150reference
- General population femalesn = 1,150reference
- T1Dn = 66,002reference
- Outcome
- Prevalence of psychiatric diagnoses
Methodological details3 large integrated health systems, matched general population referents
- 3 large integrated health systems
- Matched general population referents
Main finding
As reported in the abstract
- Depression, anxiety, personality disorders and suicidal ideation higher with CAH than general population males and females, but similar to or lower than T1D referents
- Neurodevelopmental disorders more likely with CAH than both female reference groups
- Elimination disorders (predominantly enuresis) and gender dysphoria higher with CAH than all reference groups
Observational data: associations, not effects.
Original publication
Prevalence of Psychiatric Comorbidities in Females With Classic Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. Published 4 December 2024. doi:10.
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