Adult Height Following Prepubertal Treatment With Antiandrogen, Aromatase Inhibitor, and Reduced Hydrocortisone in Congenital Adrenal Hyperplasia (CAH)
An erratum to this article was published (J Clin Endocrinol Metab, 17 Jun 2025 ↗)
Primary result · Adult height SDSResult — go to the resultMean difference 0.26 95% CI −0.29 to 0.82Authors' conclusion
Prepubertal antiandrogen, aromatase inhibitor combination with reduced hydrocortisone improves short-term predicted height for children with CAH but does not result in taller adult stature than those treated with standard therapy, and is not recommended. Females may benefit from antiandrogen treatment during puberty.
Study context
- Population
- Children with classic CAH, prepubertal45 completed
- Participants
- 62 children
- Comparison
- Prepubertal antiandrogen, aromatase inhibitor, reduced hydrocortisone and fludrocortisone vs standard therapy
- Primary endpoint
- Adult height
Methodological detailsopen
- Open
Primary result
Adult height SDS
Mean difference
0.26
95% CI −0.29 to 0.82
P = 0.35
By group
Investigational
−0.34
0.93
Control
−0.60
0.89
As reported in the abstract
- No difference irrespective of midparental height; adult height greater than pretreatment predicted adult height in both groups
- P < 0.001
Further findings
Hydrocortisone dose prior to puberty · prepubertal
P < 0.001
cm
| Outcome | Investigational | Control | Mean difference (cm) (95% CI) | P value | |
|---|---|---|---|---|---|
| Girls, antiandrogen during puberty: adult minus midparental height | −0.7 (4.6) | −5.6 (5.2) | 4.9 (0.09–9.7) | P = 0.046 | |
| −50510Difference, cm (linear scale) |
- Improvement in predicted adult height at pubertal onset · appeared greater with investigational
- P = 0.049
Hydrocortisone dose prior to puberty · prepubertal
- Growth rate and rate of bone maturation reduced with investigational regimen prior to puberty
Girls, antiandrogen during puberty: adult minus midparental height
- Antiandrogen in girls during puberty allowed lower-dose glucocorticoid
GnRHa recipients, regardless of treatment
- Lower growth rate
- P = 0.023
- Longer years of unchanged bone age
- P = 0.017
Original publication
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