Bone Mineral Density in Patients With Congenital Adrenal Hyperplasia From Prepubertal to Adult Age
Authors' conclusion
Boys and young adult men with classic form of CAH have lower BMD values compared with healthy controls. This may put them at risk of developing osteoporosis early in life.
Study context
- Population
- Patients with classic congenital adrenal hyperplasia (CAH) on lifelong glucocorticoid (GC) therapy, referral center for pediatric endocrinology
- Participants
- 56 / 60 / 36 / 51
- Exposure
- Patients with CAH on chronic GC therapy vs healthy controls
- CAHn = 56
- Healthy controlsn = 60reference
- CAH young adultsn = 36
- Young adult controlsn = 51reference
- Outcome
- BMD (lumbar spine and whole body, DXA)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
BMD
- Whole-body bone mineral density (BMD) significantly lower in patients vs healthy controls, both in boys and in girls
- No differences in lumbar spine measurements
- BMD Z-score decreased markedly in CAH patients from prepuberty to adulthood, particularly in young adult males
- Multivariate models
Observational data: associations, not effects.
Further findings
Lumbar spine BMD in men with CAH · adulthood
- Men with CAH had significantly lower lumbar spine BMD than control subjects
Original publication
Bone Mineral Density in Patients With Congenital Adrenal Hyperplasia From Prepubertal to Adult Age. J Clin Endocrinol Metab. Published 25 February 2025. doi:10.
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