The phenotype of the pediatric patient with Cushing syndrome but without obesity
Authors' conclusion
Weight gain appears to mediate some but not all the cortisol-associated complications in pediatric CS. Therefore, obesity may be a modifiable risk factor among these patients.
Study context
- Population
- Patients with young onset of cushing syndrome (CS) at ≤18 years old
- Participants
- 273 patients
- Exposure
- Pediatric CS without obesity vs with obesity
- Without obesityn = 84
- With obesityn = 189reference
- Outcome
- Demographic, biochemical and presenting findings
Main finding
As reported in the abstract
- Higher prevalence of hypertension and insulin resistance with obesity vs without, adjusting for UFC
- P < .05 for all comparisons
Observational data: associations, not effects.
Further findings
- Elevated alanine transaminase and MASLD scores more common in ACTH-dependent CS with obesity
- P < 0.05
- Fatty liver disease not statistically different in entire cohort
Original publication
The phenotype of the pediatric patient with Cushing syndrome but without obesity. Eur J Endocrinol. Published 17 September 2024. doi:10.
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