Quality of life in patients with pheochromocytoma and paraganglioma: influence of tumor type, genetics and surgical resection
Authors' conclusion
Patient-reported physical health was reduced in patients with metastatic PPGLs, unresected HNPGLs, and PV carriers without prior PPGL, whereas patients after curative PPGL resection reported QoL comparable to the general population, regardless of PV status, suggesting that annual follow-up has minimal impact on QoL.
Study context
- Population
- Patients with pheochromocytomas and paragangliomas (PPGL) before and after surgery and carriers of susceptibility pathogenic variants (PVs) for PPGLanalysed
- Participants
- 202 patients
- Exposure
- Quality of life (QoL) across PPGL subgroups
- Outcome
- Patient-reported QoL (SF-12, PHQ-D, GAD-7)
Methodological detailsProsPheo study
- ProsPheo study
Main finding
As reported in the abstract
SF-12 PCS
Metastatic PPGL
40.3
Unresected head and neck paragangliomas (HNPGL)
40.0
PV carriers after curative PPGL resection
50.2
P = 0.006
Observational data: associations, not effects.
Further findings
| Outcome | Unresected HNPGL | P value |
|---|---|---|
| SF-12 PCS within metastatic disease: hormonally active vs inactive tumoursLower with hormonally active | P = 0.03 | |
| Clinically relevant anxiety | 21.7% |
- SF-12 PCS within metastatic disease: hormonally active vs inactive tumours: Hormonally active 36.9
- SF-12 PCS within metastatic disease: hormonally active vs inactive tumours: Inactive 46.2
- Clinically relevant anxiety: PV carriers 15.2%
- Clinically relevant anxiety: General population 5.9%
- Clinically relevant anxiety: general population: about 5.9%
Original publication
Quality of life in patients with pheochromocytoma and paraganglioma: influence of tumor type, genetics and surgical resection. Eur J Endocrinol. Published 12 January 2026. doi:10.
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