Long-Term Persistence of Glycemic Dysregulation in Patients With a History of Pheochromocytoma/Paraganglioma
Authors' conclusion
Glycemic disturbances persist long-term after the resection of PPGL.
Study context
- Population
- Patients with present or past PPGL, metastatic PPGL, or asymptomatic susceptibility gene pathogenic variant (PV) carriers; ProsPheo study and ENS@T registry
- Participants
- 113 vs 76
- Exposure
- History of resected PPGL vs nonfunctioning adrenal adenomas
- History of PPGLn = 113
- Nonfunctioning adrenal adenomasn = 76reference
- Outcome
- Glycemic status after PPGL resection
- Follow-up
- ≥12 months post surgery
Methodological detailsmulticenter, ProsPheo study and ENS@T registry
- Multicenter
- ProsPheo study and ENS@T registry
Main finding
As reported in the abstract
History of PPGL
5.63
mean · SD 0.43% · % (HbA1c)
Nonfunctioning adrenal adenomas
5.45
SD 0.40% · % (HbA1c)
History of PPGL vs Nonfunctioning adrenal adenomas: P = 0.004 · History of PPGL vs Nonfunctioning adrenal adenomas: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Prevalence of hyperglycemic disorders: history of PPGL vs asymptomatic PV carriersSignificantly higher with history of PPGL | P = 0.013 |
Original publication
Long-Term Persistence of Glycemic Dysregulation in Patients With a History of Pheochromocytoma/Paraganglioma. J Clin Endocrinol Metab. Published 2 January 2025. doi:10.
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