Prognostic Significance of Preoperative Neutrophil-to-lymphocyte Ratio (NLR) or Platelet-to-lymphocyte Ratio (PLR) and PASS Score Combinations in Pheochromocytoma and Paraganglioma
Authors' conclusion
As the roles of NLR and PLR in prediction of prognosis is gaining recognition, combining these with PASS score may improve preoperative stratification of prognosis and management of patients.
Study context
- Population
- Patients with histologically confirmed pheochromocytomas/paragangliomas (pheochromocytomas and paragangliomas (PPGLs)), two centres
- Participants
- 74 patients
- Exposure
- Preoperative NLR or PLR combined with PASS score for prognosis
- Better prognosisn = 64reference
- Poor prognosisn = 10
- Outcome
- Poor prognosis: presence of metastasis or disease-specific mortality
Methodological detailstwo centres
- Two centres
Main finding
As reported in the abstract
Prediction of poor prognosis
NLR > 3.43
- AUC
- 0.761
- Sensitivity
- 70%
- Specificity
- 82.8%
- PPV
- 38.9%
- NPV
- 94.7%
PLR > 193.12
- AUC
- 0.738
- Sensitivity
- 70%
- Specificity
- 76.2%
- PPV
- 30%
- NPV
- 94%
AUC
NLR > 3.430.761
PLR > 193.120.738
Sensitivity
NLR > 3.4370%
PLR > 193.1270%
Specificity
NLR > 3.4382.8%
PLR > 193.1276.2%
PPV
NLR > 3.4338.9%
PLR > 193.1230%
NPV
NLR > 3.4394.7%
PLR > 193.1294%
Odds ratio (95% CI)P value
PASS ≥ 6 and NLR > 3.43
125(6.25-∞)
P = 0.001PASS ≥ 6 and PLR > 193.12
28.57(3–250)
P = 0.003Observational data: associations, not effects.
Further findings
Mean
| Outcome | Better prognosis | Poor prognosis |
|---|---|---|
| PASS score | 4 | 9 |
Original publication
Prognostic Significance of Preoperative NLR or PLR and PASS Score Combinations in Pheochromocytoma and Paraganglioma. Clin Endocrinol (Oxf). Published 30 December 2024. doi:10.
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