Prognostic impact of anatomic site in pheochromocytomas and paragangliomas: a population-based cohort study
Main finding · Survival by anatomic siteResult — go to the resultHR, event not stated (higher = poorer prognosis) 2.26 95% CI 1.14–4.48Authors' conclusion
The prognostic effect of anatomic site in PPGLs is stage-dependent. While location does not influence outcomes in localized disease, it becomes clinically meaningful with progression-favoring head and neck tumors and disadvantaging adrenal primaries in advanced stages. Incorporating site into stage-aware risk stratification and tailoring multimodal care for high-risk thoraco-abdominal/adrenal disease are warranted. Prospective, genotype-annotated registries should validate and refine these findings.
Study context
- Population
- Patients with histologically confirmed pheochromocytomas and paragangliomas (PPGLs), SEER 17 (2000–2022)
- Participants
- 1,468 patients
- Exposure
- Anatomic site of PPGL: adrenal vs head and neck vs thorax vs abdomen
- Outcome
- Overall and cancer-specific survival
Methodological detailspopulation-based, SEER 17 (2000-2022), propensity score matching, stage-stratified analyses
- Population-based
- SEER 17 (2000-2022)
- Propensity score matching
- Stage-stratified analyses
Main finding
Survival by anatomic site
HR, event not stated (higher = poorer prognosis)
2.26
95% CI 1.14–4.48
As reported in the abstract
- Survival outcomes varied by site; head and neck PGLs had the most favorable prognosis
- P = 0.004
Observational data: associations, not effects.
Further findings
Distribution of primary site
Original publication
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