Outcomes and Therapeutic Strategies for Head-and-neck Paragangliomas Associated With Succinate Dehydrogenase Mutations
Authors' conclusion
Most SDHx patients with monitored HNPGLs had a stable disease confirming the interest of initial time for observation before deciding to treat or not, particularly in asymptomatic patients.
Study context
- Population
- SDHx-mutated patients with head-and-neck paragangliomas (108 head-and-neck paragangliomas (HNPGL)), mostly carotid (57%) and jugulotympanic (21.5%); 97% nonsecreting and nonmetastatic; multiple tumors in 40 patients (62%)65 patients
- Participants
- 108 patients
- Exposure
- Initial surgery vs radiotherapy vs monitoring
- Surgeryn = 56
- Radiotherapyn = 21
- Monitoringn = 31
- Outcome
- Unsuccessful tumor control (UTC): tumor volume increase or need to change therapeutic strategy
- Follow-up
- 7-year median
Main finding
As reported in the abstract
Unsuccessful tumor control (UTCs) overall, in 17 patients
18
17%
Observational data: associations, not effects.
Further findings
Incomplete surgery vs Complete surgery
UTC by completeness of surgical resection
P < 0.001
Jugulotympanic (JT) vs Other locations
UTC by location
P < 0.002
Safety
| Outcome | Surgery | Radiotherapy | P value |
|---|---|---|---|
| Posttherapeutic complicationsSurgery vs Radiotherapy | 66% | 14% | P < 0.001 |
- Posttherapeutic complications — Patients with complications
- 34 (55%)
- Posttherapeutic complications — Neurological
- 73%
- Posttherapeutic complications — Vascular
- 15%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Outcomes and Therapeutic Strategies for Head-and-neck Paragangliomas Associated With Succinate Dehydrogenase Mutations. J Clin Endocrinol Metab. Published 21 April 2025. doi:10.
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