Feasibility of an Electronic Nose to Aid Biochemical Assessment of Adrenal Lesions
Authors' conclusion
While slight differences in VOC patterns were detected between functional and nonfunctional adrenal lesions, the electronic nose demonstrated limited discriminative value for clinical practice.
Study context
- Population
- Patients with pheochromocytoma (PHEO), primary hyperaldosteronism (PHA), CS or nonfunctional adrenal lesions, 2 tertiary hospitals in the Netherlands, May 2021–June 2024device A only analysed
- Participants
- 27 / 33 / 16 / 29
- Comparison
- Electronic nose breath VOC patterns in functional vs nonfunctional adrenal lesions
- PHEOn = 27
- PHAn = 33
- CSn = 16
- Nonfunctionaln = 29reference
- Outcome
- Discrimination vs nonfunctional lesions (training data)
Methodological detailspilot study, 2 tertiary hospitals, artificial neural network
- Pilot study
- 2 tertiary hospitals
- Artificial neural network
Performance
As reported in the abstract
Pooled functional lesions vs nonfunctional, AUC
0.76
PHEO vs nonfunctional, AUC
0.76
PHA vs nonfunctional, AUC
0.72
CS vs nonfunctional, AUC
0.58
Further findings
- Model performance declined significantly on test data, with wide CIs across all comparisons
Original publication
Feasibility of an Electronic Nose to Aid Biochemical Assessment of Adrenal Lesions. Endocr Pract. Published 15 April 2025. doi:10.
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