Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity
Authors' conclusion
A short-term low-calorie diet led to a multifaceted body response in patients with obesity, with an increase in connectivity in the limbic-temporal network (emotion and memory) and hormone and eating behavior changes that may be important for recovering the weight lost.
Study context
- Population
- Individuals with obesity, 9 with T2D9 with T2D
- Participants
- 25 individuals
- Comparison
- After vs before an 8-week low-calorie diet
- Outcome
- Brain connectivity in response to changes in glucose levels after diet-induced weight loss
- Follow-up
- 8 weeks
Methodological detailsbefore-after, two-step hypereuglycemia clamp, task-mediated functional magnetic resonance imaging (fMRI) intrinsic connectivity distribution analysis
- Before-after
- Two-step hypereuglycemia clamp
- Task-mediated fMRI intrinsic connectivity distribution analysis
Main finding
As reported in the abstract
Brain connectivity · after 8-week diet
- Greater brain connectivity in the parahippocampus, right hippocampus and temporal cortex (limbic-temporal network) after diet-induced weight loss
- Group differences (with vs without T2D) in several brain networks
- Connectivity in limbic-temporal and frontal-parietal clusters inversely correlated with hunger
Further findings
Body weight · after 8-week diet
- Average body weight loss
- 3.3%
Leptin, hunger and food intake · after 8-week diet
- Decrease in leptin levels; increase in hunger and food intake
Original publication
Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity. Obesity (Silver Spring). Published 3 June 2024. doi:10.
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