Sarcopenic Obesity and Outcomes for Patients With Cancer
Authors' conclusion
This cohort study of SO found that SO was significantly associated with lower OS, poorer QoL, and higher risk of ICU admission. Weak HGS, 1 of the diagnostic conditions, was the only component of SO associated with OS. The ESPEN-EASO algorithm appears to be an applicable tool to identify cancer-associated SO, which represents a major clinical complication and factor associated with risk for poor outcomes in these patients.
Study context
- Population
- Patients diagnosed with solid tumor cancers, May 7, 2013 onward; mean age 59.64 years, 51.4% female2,103 died
- Participants
- 6,790 patients
- Exposure
- Sarcopenic obesity vs non-SO by ESPEN-EASO criteria
- Sarcopenic obesity (SO)n = 296
- Outcome
- Overall survival (OS)
- Follow-up
- Median 6.83 (IQR 5.67-7.04) years
Main finding
OS
Hazard ratio
1.54
95% CI 1.23–1.92
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| OS in men | HR 1.51 (95% CI 1.09–2.10) | |
| OS in women | HR 1.53 (95% CI 1.12–2.07) | |
| ICU admissionHigher risk with SO | OR 2.39 (95% CI 1.06–5.29) | |
| 0.20.5125Ratio (log scale) |
Prevalence of SO
- Whole cohort
- 4.36% (296 of 6790)
- Subgroup with obesity
- 14.98% (296 of 1976)
- SO prevalence increased with age
Quality of life (QoL)
- SO associated with poorer QoL
Overall survival (OS) by SO component: low hand grip strength (HGS)
- Low HGS was the only SO component associated with poor OS
- HR 1.15 (95% CI 1.04-1.28)
Original publication
Sarcopenic Obesity and Outcomes for Patients With Cancer. JAMA Netw Open. Published 3 June 2024. doi:10.
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