Evolution of myocardial steatosis in high cardiovascular risk T2DM patients treated by GLP1 receptor agonists: LICAS study
Main finding · Relative change (Δr) in intramyocardial triglyceride levels vs baselineResult — go to the resultMean Δr −26 % 95% CI −39 to −13Authors' conclusion
We demonstrate a significant reduction in intramyocardial triglyceride content in patients with T2D after six months of treatment with GLP1-RA. The lack of correlation with reductions in HbA1c and BMI suggests a specific effect of GLP1-RA on myocardial steatosis, which might contribute to their previously demonstrated cardiovascular benefits.
Study context
- Population
- Patients with unbalanced T2D prior to the introduction of GLP-1 RA; mean age 62.2 ± 6.7 years, median HbA1c 9.1 %
- Participants
- 26 patients
- Exposure
- Baseline vs 6 months after GLP-1 RA introduction
- GLP-1 RAn = 26
- Outcome
- Change in intramyocardial triglyceride content
- Follow-up
- Six months
Methodological detailsmonocentric, proof-of-concept
- Monocentric
- Proof-of-concept
Main finding
As reported in the abstract
Relative change (Δr) in intramyocardial triglyceride levels vs baseline
Mean Δr
−26 %
95% CI −39 to −13
P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| HbA1c relative change · six monthsM6 vs Baseline · IQR 25 | median Δr −26 % | P < 0.0001 |
| BMI relative change · six monthsM6 vs Baseline | mean Δr −6 % (CI −9 to −4) | P < 0.0001 |
| Left ventricular mass relative change · six monthsM6 vs Baseline | mean Δr −6 (CI −12 to −1) | P = 0.02 |
Correlation of intramyocardial TG change with HbA1c and body mass index (BMI) change
- Not correlated with relative change in HbA1c (r)
- 0.10
- Not correlated with relative change in BMI (r)
- −0.02
Original publication
Evolution of myocardial steatosis in high cardiovascular risk T2DM patients treated by GLP1 receptor agonists: LICAS study. Diabetes Res Clin Pract. Published 1 February 2025. doi:10.
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