Potential Mechanism Associated with Post–Heart Transplantation Diabetes Mellitus in Chinese Patients
Authors' conclusion
These findings may provide a novel understanding of the pathological mechanism of PTDM and could be used to predict the development and progression of PTDM.
Study context
- Population
- Adult heart transplantation (HT) recipients followed for more than 1 year
- Participants
- 106 recipients
- Comparison
- Posttransplantation diabetes mellitus (PTDM) vs non-PTDM HT recipients
- PTDMn = 56
- Non-PTDMn = 50reference
- Outcome
- Differentially abundant metabolites
Methodological detailsuntargeted metabolomics, UHPLC-MS/MS
- Untargeted metabolomics
- UHPLC-MS/MS
Main finding
As reported in the abstract
Metabolites detected
1174
Significantly differentially abundant metabolites (VIP > 1; P < .05; FC > 1.5 or <0.67)
99
Further findings
| Outcome | P value |
|---|---|
| Clinical characteristicsPTDM vs non-PTDM | P = 0.003 |
| Clinical characteristicsPTDM vs non-PTDM | P = 0.010 |
| Clinical characteristicsPTDM vs non-PTDM | P = 0.007 |
| Clinical characteristicsPTDM vs non-PTDM | P = 0.001 |
Original publication
Potential Mechanism Associated with Post–Heart Transplantation Diabetes Mellitus in Chinese Patients. J Clin Endocrinol Metab. Published 1 February 2025. doi:10.
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