Interrupting prolonged sitting with frequent short bouts of light‐intensity activity in people with type 1 diabetes improves glycaemic control without increasing hypoglycaemia: The sitting (SIT)‐LESS randomised controlled trial
Authors' conclusion
Interrupting prolonged sitting with frequent short bouts of light-intensity activity improves acute postprandial and 48-h glycaemia in adults with T1D. This pragmatic strategy is an efficacious approach to reducing sedentariness and increasing physical activity levels without increasing risk of hypoglycaemia in T1D.
Study context
- Population
- Inactive adults with T1D; aged 27.9 ± 4.7 years, 15 men, diabetes duration 16.0 ± 6.9 years, HbA1c 8.4 ± 1.4%crossover
- Participants
- 32 adults
- Comparison
- Interrupted sitting with 3-min walking bouts every 30 min (SIT-LESS) vs uninterrupted sitting (SIT)
- Primary endpoint
- Glycaemic control (total mean glucose by blinded CGM)
- Follow-up
- 7-h experimental period and further 48-h free-living
Methodological details>7-day washout, blinded CGM, Standardised mixed-macronutrient meals 3.5 h apart during each 7-h condition
- >7-day washout
- Blinded CGM
- Standardised mixed-macronutrient meals 3.5 h apart during each 7-h condition
Primary result
As reported in the abstract
P = 0.001
Further findings
TIR (3.9-10.0 mmol/L)
increase 13.7 % · P = 0.002
Hyperglycaemia (>10.0 mmol/L) · lower with SIT-LESS
reduction 15.0 % · P = 0.002
| Outcome | Reduction (%) | P value |
|---|---|---|
| Glycaemic variability (CV %) · across the observation windowLower with SIT-LESS | 7.8 | P = 0.021 |
Discrete periods: experimental and free-living postprandial, whole-day and night-time glycaemia
- SIT-LESS improved experimental and free-living postprandial, whole-day and night-time glycaemic outcomes
- P < 0.05
Safety
Hypoglycaemia exposure (<3.9 mmol/L) · comparable across conditions
P = 0.583
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →