Vascular and Myocardial Structure and Function in Adolescents with Type 1 Diabetes: The CARDEA Study
Authors' conclusion
In addition to higher BP and abnormal lipid profiles, adolescents with type 1 diabetes present endothelial dysfunction and alterations in cardiac structure (in boys) compared to adolescents without diabetes, suggesting that CVD prevention should be incorporated into type 1 diabetes management early in the disease.
Study context
- Population
- Adolescents aged 14–18 years with and without T1D, CARDEA study
- Participants
- 100 vs 97
- Exposure
- Adolescents with T1D vs without diabetes
- T1Dn = 100
- Without diabetesn = 97reference
- Outcome
- Cardiovascular disease (CVD) risk factors and early markers (adjusted for age, sex, ethnicity, adiposity, familial income)
Main finding
As reported in the abstract
T1D vs Without diabetesDifference in LDL-C, mmol/L (95% CI)
CVD risk factors and early markers (adjusted for age, sex, ethnicity, adiposity, familial income)
0.21(0.02–0.40)
T1D vs Without diabetesDifference in TG, % (95% CI)
CVD risk factors and early markers (adjusted for age, sex, ethnicity, adiposity, familial income)
17(4–29)
- Higher with T1D
- difference in diastolic blood pressure (BP) z-score 0.21 SD (95% CI 0.04–0.38)
- Lower with T1D
- difference in endothelial function (flow-mediated dilation acceleration) −77.4 cm/s2 (95% CI −133.1 to −21.6)
Observational data: associations, not effects.
Further findings
Effect modification by sex
- Girls with T1D had higher systolic BP z-score than healthy peers
- Boys with T1D had lower left ventricular (LV) mass and wall thickness than healthy peers
Original publication
Vascular and Myocardial Structure and Function in Adolescents with Type 1 Diabetes: The CARDEA Study. Pediatr Diabetes. Published 24 August 2023. doi:10.
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