Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes
Authors' conclusion
This proof of concept that routine capillary ketone surveillance can identify individuals at high risk of future DKA implies a role for future technologies including continuous ketone monitoring.
Study context
- Population
- Placebo-assigned participants with T1D in an adjunct-to-insulin medication trial program; fasted capillary blood ketones measured twice per week in a 2-month baseline period
- Participants
- 484 participants
- Comparison
- Patient cases vs control patients
- Patient casesn = 12
- Primary endpoint
- Trial-adjudicated DKA
- Follow-up
- 6 to 12 months
Methodological detailsprognostic accuracy analysis, previously collected data
- Prognostic accuracy analysis
- Previously collected data
Primary result
As reported in the abstract
P = 0.002
- Nonparametric AUC for maximum ketone levels
- 0.77 (95% CI 0.66-0.88)
- Ketone ≥0.8 mmol/L: sensitivity
- 64%
- Ketone ≥0.8 mmol/L: specificity
- 78%
- Ketone ≥0.8 mmol/L: positive likelihood ratio
- 2.9
- Ketone ≥0.8 mmol/L: negative likelihood ratio
- 0.5
Further findings
Diabetic ketoacidosis (DKA) events
- Participants with DKA
- 12 of 484
- Time to DKA, median (IQR 43, 199) days
- 105
Original publication
Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes. Diabetes Care. Published 24 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →