Effect of Interrupting Prolonged Sitting with Frequent Activity Breaks on Postprandial Glycemia and Insulin Sensitivity in Adults with Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion Therapy: A Randomized Crossover Pilot Trial
Authors' conclusion
Regularly interrupting prolonged sitting in T1D may increase plasma insulin and improve insulin sensitivity when meals and CSII are standardized.
Study context
- Population
- Adults with T1D on continuous subcutaneous insulin infusion (CSII); age 46 ± 14 years, BMI 27.2 ± 3.8 kg/m²; basal and bolus insulin standardized across conditionscrossover
- Participants
- 8 adults
- Comparison
- Sitting interrupted with simple resistance activities (SRA) vs uninterrupted sitting (SIT)
Methodological detailsmixed models adjusted for sex, BMI, treatment order and preprandial values
- Mixed models adjusted for sex, BMI, treatment order and preprandial values
Primary result
As reported in the abstract
Glucose iAUC · 6 h
P = 0.086
Further findings
Estimated marginal mean, mmol.mU-1
| Outcome | SRA | SIT | P value |
|---|---|---|---|
| Glucose response relative to plasma insulin change (tAUCglu/tAUCins) · 6 hLower with SRA | 0.32 (SE 0.02) | 0.40 (SE 0.02) | P = 0.03 |
- Insulin incremental area-under-the-curve (iAUC) · 6 h · higher with SRA · despite CSII standardized between conditions
- P < 0.001
Meal-based insulin sensitivity (sensor and insulin pump (SiSP))
- SiSP higher at dinner following SRA; no between-condition differences at breakfast or lunch
Original publication
Effect of Interrupting Prolonged Sitting with Frequent Activity Breaks on Postprandial Glycemia and Insulin Sensitivity in Adults with Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion Therapy: A Randomized Crossover Pilot Trial. Diabetes Technol Ther. Published 7 November 2024. doi:10.
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