Short, frequent, light‐intensity walking activity improves postprandial vascular‐inflammatory biomarkers in people with type 1 diabetes: The SIT‐LESS randomized controlled trial
Authors' conclusion
Interrupting prolonged sitting with light-intensity activity ameliorates postprandial increases in vascular-inflammatory markers in T1D.
Study context
- Population
- Adults with T1D (mean ± SD age 28 ± 5 years, HbA1c 67.9 ± 12.6 mmol/mol, 17 women); two 7-h laboratory visits separated by >7 days
- Participants
- 32 adults
- Comparison
- Interrupting prolonged sitting with 3-min self-paced walking bouts every 30 min (SIT-LESS) vs uninterrupted sitting (SIT)
- Primary endpoint
- Postprandial vascular-inflammatory markers (plasma IL-1β, TNF-α, PAI-1, fibrinogen)
- Follow-up
- Baseline, 3.5 and 7 h
Methodological detailsPhysical activity, insulin regimen, experimental start times and meal consumption standardized during each arm
- Physical activity, insulin regimen, experimental start times and meal consumption standardized during each arm
Primary result
As reported in the abstract
Postprandial change in TNF-α, IL-1β, PAI-1 and fibrinogen · 7 h
| Group | Tumour necrosis factor (TNF)-α change | IL-1β change | PAI-1 change | Fibrinogen change |
|---|---|---|---|---|
| SIT | +67% | +49% | +49% | +62% |
| SIT-LESS | −22% | −9% | −42% | −44% |
Tumour necrosis factor (TNF)-α change
SIT+67%
SIT-LESS−22%
IL-1β change
SIT+49%
SIT-LESS−9%
PAI-1 change
SIT+49%
SIT-LESS−42%
Fibrinogen change
SIT+62%
SIT-LESS−44%
- SIT-LESS vs SIT: P < 0.001 — rises in TNF-α, IL-1β, PAI-1 and fibrinogen attenuated under SIT-LESS
- SIT: increases in TNF-α, IL-1β, PAI-1 and fibrinogen
- P < 0.001 for all
- SIT-LESS: no change in IL-1β
- P > 0.50
- SIT-LESS: reductions in TNF-α, PAI-1 and fibrinogen
- P < 0.001 for all
Further findings
| Outcome | P value |
|---|---|
| Vascular-inflammatory parameters at baselineComparable | P > 0.05 |
Effect by insulin resistance status (estimated glucose disposal rate)
- The intervention showed enhanced effects in insulin-resistant individuals with T1D
Original publication
Short, frequent, light‐intensity walking activity improves postprandial vascular‐inflammatory biomarkers in people with type 1 diabetes: The SIT‐LESS randomized controlled trial. Diabetes Obes Metab. Published 1 April 2024. doi:10.
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