Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes
Authors' conclusion
DKA causes a unique inflammatory pattern distinct from inflammatory changes in acute hyperglycemia or T1D-related autoimmunity. Alterations in MMPs and their tissue inhibitors play a dominant role in this inflammatory profile.
Study context
- Population
- Children with T1D, with or without diabetic ketoacidosis (DKA)
- Participants
- 15 / 14 / 9 / 14 / 59
- Exposure
- Children with acute DKA, post-DKA and new-onset T1D without DKA vs children with chronic T1D (reference)
- Acute DKAn = 15
- 2-5 days after DKAn = 14
- New-onset T1D without DKA <24 hoursn = 9
- New-onset T1D without DKA 2-5 daysn = 14
- Referencen = 59reference
- Outcome
- Inflammatory profile (cytokines, chemokines, growth factors, MMPs) during and after DKA
Methodological detailsmultiplex immunoassays
- Multiplex immunoassays
Main finding
As reported in the abstract
Inflammatory mediators vs reference group
- Acute DKA: significant alterations in IL-1RA, IL-6, IL-8, IL-10, IL-18, CXCL5, CXCL10, CCL27, TRAIL, G-CSF, TIMP-2, TIMP-4, MMP-2, MMP-3, MMP-7, MMP-9 and MMP-10
- 2-5 days after DKA: MMP-3, MMP-10, TIMP-1 and IL-1RA also elevated
- New-onset T1D without DKA <24 h after insulin: MMP-2 and MMP-9 altered
- New-onset T1D 2-5 days after insulin: no significant inflammatory changes
- False discovery rate-adjusted p<0.10 for all
Observational data: associations, not effects.
Original publication
Inflammatory profile of diabetic ketoacidosis in children with type 1 diabetes. BMJ Open Diabetes Res Care. Published 10 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →