Longitudinal changes in epigenetic age acceleration prior to type 1 diabetes onset in the Diabetes Autoimmunity Study in the Young (DAISY)
Authors' conclusion
These results suggest that EAA occurs in children who develop type 1 diabetes prior to IA seroconversion, highlighting the potential role of early environmental stressors in disease pathogenesis.
Study context
- Population
- Children born 1993–2006 at high risk for T1D in the Diabetes Autoimmunity Study in the Young (DAISY) cohort (2547 children)from cohort of 2547
- Participants
- 85 vs 85
- Comparison
- T1D cases vs controls, change in epigenetic age acceleration (EAA) before and after islet autoimmunity (IA) seroconversion
- Casesn = 85
- Controlsn = 85reference
- Outcome
- Change in epigenetic age acceleration (EAA), estimated from DNA methylation with a pediatric epigenetic clock
- Follow-up
- Pre-IA to post-IA seroconversion
Methodological detailslongitudinal, linear mixed model
- Longitudinal
- Linear mixed model
Main finding
As reported in the abstract
Change in EAA
- EAA significantly decreased in cases, pre-IA to post-IA, by 0.367 units (95% CI −0.64 to 0.09)
- p=0.01
- No significant change in EAA in controls: 0.045 (95% CI 0.23 to 0.32)
- p=0.75
Observational data: associations, not effects.
Original publication
Longitudinal changes in epigenetic age acceleration prior to type 1 diabetes onset in the Diabetes Autoimmunity Study in the Young (DAISY). BMJ Open Diabetes Res Care. Published 10 March 2026. doi:10.
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