A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes
Authors' conclusion
IA increased among Colorado children born 1993-2010, with the strongest effects among moderate-risk HLA genotypes in later BCs.
Study context
- Population
- Colorado children born 1993–2010 in Diabetes Autoimmunity Study in the Young (DAISY) and The Environmental Determinants of Diabetes in the Young (TEDDY)
- Participants
- 2,734 children3 birth cohorts
- Exposure
- Birth cohorts BC2 and BC3 vs BC1
- Outcome
- Islet autoimmunity (IA) incidence
Methodological detailsthree birth cohorts, Cox models with time-varying coefficients, BC-HLA interaction, mediation analyses
- Three birth cohorts
- Cox models with time-varying coefficients
- BC-HLA interaction
- Mediation analyses
Main finding
As reported in the abstract
IA
Observational data: associations, not effects.
Further findings
| Outcome | Times the IA risk |
|---|---|
| IA risk, moderate-risk HLA participants · age 1 yearBC2 vs BC1 | 2.57 |
| IA risk, moderate-risk HLA participants · age 1 yearBC3 vs BC1 | 6.19 |
Islet autoimmunity (IA) risk, moderate-risk HLA participants · age 1 year
- By age 5 years, effects attenuated
Mediation by environmental exposures (age at gluten introduction, weight-for-age Z-score, maternal smoking)
- No selected environmental exposures mediated the increased incidence
Original publication
A Secular Increase in the Incidence of Islet Autoimmunity Among Colorado Children With Moderate-Risk HLA Genotypes. Diabetes Care. Published 1 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →