Increased Levels of the Vitamin D Metabolite Ratio Are Protective Against Progression From Islet Autoimmunity to T1D
Main finding · Progression from IA to T1DResult — go to the resultHazard ratio per 1 SD increase 0.65 95% CI 0.49–0.88Authors' conclusion
A higher VMR, a more functional measure of vitamin D status, was protective against T1D progression, perhaps by decreasing activation of inflammatory pathways.
Study context
- Population
- Participants at high genetic risk for T1D who developed islet autoimmunity (IA) in the Diabetes Autoimmunity Study in the Young (DAISY)gene expression subset n = 53
- Participants
- 143 participants
- Exposure
- Higher vs lower vitamin D metabolite levels and ratios at IA seroconversion
- Outcome
- Progression from IA to T1D
Methodological detailsT1D birth cohort (DAISY)
- T1D birth cohort (DAISY)
Main finding
As reported in the abstract
exposure at IA seroconversion
Hazard ratio per 1 SD increase
0.65
95% CI 0.49–0.88
Higher VMR (per 1 SD increase)
HR per 1 SD increase 0.65 (95% CI 0.49–0.88)
Per 1 SD increase, as printed
- Progressed to T1D
- 57/143
Observational data: associations, not effects.
Further findings
Gene expression in whole blood
- Higher VMR associated with gene expression pattern of decreased activation of inflammatory pathways related to neutrophil infiltration (functional enrichment analysis)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Increased Levels of the Vitamin D Metabolite Ratio Are Protective Against Progression From Islet Autoimmunity to T1D. J Clin Endocrinol Metab. Published 30 October 2025. doi:10.
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