HLA‐C ∗ 0304 Associates With Beneficial Gut Microbiota and Later Onset of Type 1 Diabetes in Pediatric Cohorts
Authors' conclusion
Our study demonstrates that specific HLA class I subtypes (e.g., C ∗ 0304) may modulate T1DM onset through selective enrichment of beneficial gut microbiota. Elucidating the mechanisms by which HLA variants regulate mucosal immunity and coordinate HLA-microbiota-immune interactions holds significant potential for developing targeted interventions against T1DM pathogenesis.
Study context
- Population
- Newly diagnosed paediatric T1D patients (age <18 years) and healthy controls from nine Chinese cities
- Participants
- 106 vs 69
- Exposure
- Newly diagnosed paediatric T1D patients vs healthy controls, stratified by HLA-risk scores; HLA-C∗0304 carriers vs noncarriers
- T1DMn = 106
- Healthy controlsn = 69reference
- Outcome
- Gut microbiota structure (PCoA) and T1D onset by HLA
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
R 2
0.0562
P = 0.003
High-HLA-risk T1DM vs High-HLA-risk controls · discernible disparities in gut microbiota structures
R 2
0.0343
P = 0.003
High-HLA-risk T1DM vs Low-HLA-risk controls · discernible disparities in gut microbiota structures
Adjusted R 2
0.225
P = 0.017
HLA-C∗0304 carriers vs Noncarriers · delayed T1D onset in carriers
Observational data: associations, not effects.
Further findings
Fasting C-peptide · lower with high-HLA-risk
P = 0.029
Gut taxa in HLA-C∗0304-positive T1D patients
- Enriched Blautia
- P = 0.005
- Enriched Lachnospiraceae
- P = 0.039
- Lower opportunistic pathogens (Citrobacter)
- P < 0.05
Original publication
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