Effectiveness and safety of early insulin glargine administration in combination with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: A randomized controlled trial
Authors' conclusion
Early combination of insulin glargine with IV insulin infusion led to a faster DKA resolution and a shorter LOS, without increasing hypoglycaemia and hypokalaemia.
Study context
- Population
- Adults aged 18 years or older diagnosed with diabetic ketoacidosis (DKA); 76.7% had T2D30 per group
- Participants
- 60 adults
- Comparison
- Early SC insulin glargine plus intravenous (IV) insulin infusion vs IV insulin infusion alone
- Early glarginen = 30
- Controln = 30reference
- Primary endpoint
- Time to DKA resolution
Methodological detailssingle-centre, open-label
- Single-centre
- Open-label
Primary result
As reported in the abstract
P = 0.022
Further findings
LOS · significantly shorter with early glargine
P = 0.024
Rebound hyperglycaemia and all-cause mortality
- Incidence of rebound hyperglycaemia and all-cause mortality similar between groups
Safety
- Incidence of hypoglycaemia and hypokalaemia similar between groups
Original publication
Effectiveness and safety of early insulin glargine administration in combination with continuous intravenous insulin infusion in the management of diabetic ketoacidosis: A randomized controlled trial. Diabetes Obes Metab. Published 20 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →